Annex A Summary of concepts in Forensic Toxicology

This document contains keywords of concepts of which an expert in the field of Forensic Toxicology should minimally have a basic knowledge

1. Human biology

  • Anatomy, physiology, biochemistry

2. Pathology

  • Pathophysiology and biochemical pathology
  • Clinical chemistry
  • Basics of pathological anatomy

3. Pharmacology and Toxicology

  • Pharmaco/toxicodynamics
  • Pharmaco/toxicokinetics, including the effect of dosage forms (biopharmacy)
  • Pharmaco/toxicogenetics
  • Chemical structures: structure-activity relationships, working mechanisms, metabolism of xenobiotics
  • General toxicology: acute versus chronic toxicity; carcinogenicity, mutagenicity, teratogenicity
  • Clinical toxicology: symptoms and therapy in the event of overdose organ toxicity, side effects, interactions, addiction and habituation, effects of drugs on behaviour, clinical chemistry (influence of poisoning on clinical-chemical parameters)
  • Pathophysiology and biochemical pathology
  • Epidemiology of acute poisoning
  • Risk assessment of possible poisonous substances

4. Post-mortem toxicology

  • Sampling, choice of material to be examined and analysed (in this context the interpretation of autopsy and necropsy/legal post-mortem results are important)
  • Post-mortem processes in bodily material (causes and effects)

5. Bio-analytical investigation

  • Method development and method specifications (quality, quantity): pre-treatment, separation and detection
  • Method validation: quality requirements
  • Quality control
  • Stability: storing, preserving
  • Certification and accreditation
  • External Quality Assurance